D-Mannitol Technical Specifications
*(C₆H₁₄O₆ | CAS No.: 69-65-8 | EC No.: 200-711-8)*
1. Fundamental Properties
| Parameter | Specification |
|---|---|
| Molecular Weight | 182.17 g/mol |
| Appearance | White crystalline powder |
| Melting Point | 167-170°C |
| Solubility | 213 g/L in water (20°C) |
| pH (10% sol.) | 5.0-7.0 |
| Sweetness | 70% of sucrose |
2. Key Applications
A. Pharmaceutical
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Osmotic diuretic: Reduces intracranial/intraocular pressure
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Excipient: Tablet filler (direct compression), lyophilization stabilizer
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Diagnostic agent: Renal function tests
B. Food Industry
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Low-calorie sweetener (E421)
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Anti-caking agent in chewing gums/sweets
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Sugar-free product formulations
C. Microbiology
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Carbon source in culture media (e.g., Mannitol Salt Agar)
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Fermentation studies
3. Safety & Handling
| Aspect | Detail |
|---|---|
| Glycemic Index | Low (GI=0) |
| Storage | ≤25°C, dry environment |
| Explosion Risk | Dust-air mixtures may be combustible |
| Regulatory Status | GRAS (FDA), EFSA-approved |
4. Quality Standards
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Purity: ≥98% (HPLC)
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Residues: Heavy metals ≤10 ppm
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Microbial Limits: TAMC <100 CFU/g
5. Comparative Advantages
✔ Renal-safe diuretic (minimal tubular reabsorption)
✔ Tooth-friendly sweetener (non-cariogenic)
✔ High chemical stability in formulations
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